Health

Mannitol-stimulated Copeptin for diagnosing Arginine Vasopressin Deficiency: a randomized controlled proof of concept and a single-arm pilot study

Opposing microbiome-mediated axes link modifiable lifestyles to health and chronic diseases

Human responses to graded light exposure in the temporal visual field during central visual tasks

Novel platform recapitulates microbe–gut–cartilage axis in vitro

Knowledge, attitude, and perception of cardiac and pulmonary telerehabilitation among physiotherapists in India

Dynamic patterns of body size and mortality among older adults in China: Evidence from a multi-city cohort study

Correction: Zanubrutinib combined with R-CHOP in previously untreated diffuse large B-cell lymphoma with specific gene alteration: a phase II study

Diagnostic concordance of modified NCEP-ATP III and IDF criteria for screening metabolic syndrome among Yemeni medical students

Exposure to legitimate and illegal online medicine vendors via search engines in 30 European countries

Acute upper respiratory tract infections in adults: a multidisciplinary position statement for optimal symptom management in Asia-Pacific

Dietary patterns derived by RRR and PCA in relation to insulin resistance and adiposity: a cross-sectional study

Biomechanical effects of fixed retainer designs under different labiolingual alveolar bone loss conditions: a finite element analysis

Maternal consumption of red meat and ultra-processed foods during pregnancy and risk of postpartum depression: a prospective cohort study

Cross-site pooling with feature harmonization for small-for-gestational-age (SGA) prediction across heterogeneous feature spaces

Correction: T-cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: a study from the ALWP/EBMT

Network analysis of symptom severity and symptom distress in hospitalized patients with decompensated cirrhosis

Real-world feasibility of a nutritional frailty score-guided multimodal supportive care pathway in patients with digestive cancer

CT radiomics for predicting thoracic vertebral compression fractures after radiotherapy in esophageal squamous cell carcinoma: a two-center retrospective study

Association between time spent on internal medicine attending rounds and in training examination scores among resident physicians in Japan

Non-prescription antibiotic dispensing in community drug retail outlets in Central Gondar, Ethiopia: a mixed-methods study

Collaborative generalist-specialist AI for safe worklist deprioritization of non-contrast brain computed tomography

Prevalence and association of adverse childhood experiences among voluntarily-admitted substance use disorder inpatients in Thailand

Distal electrical stimulation produces facial nerve regenerative and anti-synkinetic effects comparable to proximal electrical stimulation

Recognition of intracranial hypertension in children with craniosynostosis using handheld OCT: a diagnostic accuracy study

Evaluation of treatment response in patients with recurrent grade 4 glioma using hyperpolarized [1-13C]pyruvate MRI

Resident cardiac macrophage-like cells induced by an ILC2 cytokine cocktail confer cardioprotection through enhanced efferocytosis in a mouse model of myocardial infarction

Home non-invasive ventilation reduces hospitalizations, and healthcare costs in adult patients with severe chronic obstructive pulmonary disease

Association of imipenem/cilastatin with development of acute kidney injury in critically ill patients requiring carbapenem treatment

Dipyridamole analogs uncouple two dipyridamole activities: induction of cancer cell death and inhibition of platelet aggregation

Impact of social media-based health campaigns on knowledge, belief, and self-reported behavior during COVID-19

Interpretable machine learning for postoperative atrial fibrillation after noncardiac surgery

Proposal for new cut-off points for vital signs used to identify at-risk patients over 65 years old in Emergency Departments

Bindarit ameliorates doxorubicin-induced ovarian damage by suppressing CCL8-dependent macrophage infiltration and NF-κB-mediated inflammation

Hierarchical AI classification of benign laryngeal disorders using acoustic voice features

Refinement is the ugly duckling of the 3Rs

Inflammatory biomarker profiles and their associations with Nordic dietary habits and metabolic outcomes in adults affected by MAFLD

Multimodal deep learning with clinical metadata for skin lesion classification

Changes in the scope and intent of US state legislation on ivermectin and pharmacy dispensing trends, 2020–2026

Choroid plexus enlargement as an imaging correlate of cognitive impairment in Parkinson’s disease: a normative brain-charts analysis

SPOTnet: weakly-supervised specular reflection detection and removal for minimally invasive surgery

Pericyte-derived exosomal hexokinase 2 promotes retinal neovascularization via non-metabolic ELK3 upregulation

Pharmacogenomics guided clopidogrel utilization in veterans undergoing peripheral arterial intervention with vascular surgery compared to usual care

Documented SARS-CoV-2 infection and risk of neurodegenerative disease diagnosis: a target trial emulation across three real-world cohorts

Evaluation of an audio-based monitoring system for detecting retching and vomiting in gastroparesis: an observational cohort study

Establishment and characterization of an HFD-induced mouse model of obesity-associated male hypogonadism

Advances in preterm birth prediction integrating global evidence with a focus on China

Quality and engagement of rosacea-related short videos on Chinese platforms RedNote and TikTok: a cross-sectional analysis

Global temperature-related mortality associated with El-Nino Southern Oscillation

Comparative evaluation of pulmonary aspergillosis information generated by large language model-based chatbots

Maternal weight gain at embryonic day 8.5 predicts ongoing pregnancy in timed-mated mice

Swallowing biomechanics and upper esophageal sphincter pressure remain altered after esophagectomy for thoracic esophageal cancer

Carbon monoxide accumulation and oxygen depletion during butane heater operation in an enclosed tent

Amharic medical question answering system using AmhBERT

Deep learning-based binary classification and probabilistic calibration of navicular bone pathology in equine radiographs

Development of a biomimetic hydrogel cervical spinal cord surrogate for transverse compression across loading rates

Factors associated with TyG-BMI among pre-frail older adults: a cross-sectional study using multiple linear regression and decision tree analysis

Early longitudinal lactate-to-albumin ratio and mortality in critically ill adults: a temporally aligned multicohort study

Deep learning for odontoid fractures: the critical role of patient-level partitioning and Grad-CAM assessment in model generalization

Cumulative and persistent glycemic–renal burden and incident cardiovascular disease in the Health and Retirement Study

Data suggest a shift in the approach to Alzheimer’s disease prevention and treatment is warranted

A tumor transcriptomic atlas across eight decades of life reveals distinct features of early-onset colorectal cancer

UBE2T upregulation underlies the metastasis-associated chemoresistance of breast cancer that can be reversed by BET inhibitors

Association between gut microbiome signature and blood pressure in children: findings from a Chinese cohort study

Oculomotor and clinical correlates with impaired optokinetic nystagmus in Parkinson’s disease

Cumulative exposure to TyG-BRI and risk of incident cardiovascular disease across CKM syndrome stages 0–3: evidence from the CHARLS Prospective Cohort

China’s elite championship output during and after the COVID-19 disruption: competition opportunities and Olympic/Paralympic cycle structure, 2013–2025

Acute effects of unilateral and bilateral split-squat conditioning on change-of-direction performance in elite fencers

fNIRS and eye tracking reveal observation-practice ratio-dependent neural efficiency in multi-level 24-style tai chi learning

Sex dimorphism in lung ischemia-reperfusion injury reveals a protective role of 17β-estradiol via PI3K/AKT/GSK-3β pathway in male rats

Sleep impairment is associated with higher predicted cardiovascular risk and increased atherosclerotic burden in an experimental mouse model

Comparison of four insulin resistance surrogate indices for incident MASLD in Chinese and prevalent MASLD in Japanese nonobese adults

Four resistance training protocols for upper-body strength and punch performance in elite female boxers: a randomized controlled trial

Comparison of selected CNN and transformer models for choledocholithiasis classification and localization on MRCP

MedGenAgent: a closed-loop agent for oncology CT foundation model pretraining

Temporal trends and disparities in cardiac arrest and co-listed acute myocardial infarction-related mortality in the United States, 1999–2025: Insights from CDC WONDER database

Alternate eye patching improves long-term alignment stability after surgery for intermittent exotropia: a randomised controlled trial

Proton pump inhibitor/histamine-2 receptor blocker exposure and ocular toxoplasmosis: a nationwide claims-based study

Erector spinae muscle fibre size estimation using high-density surface electromyography in people with and without non-specific chronic low back pain: a cross-sectional study

Association of the planetary health diet index with overweight and obesity among patients with diabetes mellitus in a cross sectional study

Spectrum of viral infections and asymptomatic viral shedding in a cohort of Indian children with inborn errors of immunity

Patient-anatomy-referenced multiscale modelling of median nerve conduction in carpal tunnel syndrome

Artificial intelligence-assisted ECG interpretation for identification of occlusive myocardial infarction following cardiac arrest: a multi-reader, multi-case study

Mortality and survival rates following lower limb amputation: a national observational cohort study in Sweden

The first attempts to transplant bone marrow—tribute to Jan Raszek-Rosenbusch and Franciszek Groër.

Sex differences in inflammation, mitochondrial function and energy sensing during early recovery from COVID 19 in older adults

Longitudinal single-cell profiling of breast tumors highlights immune and epigenetic mechanisms associated with sensitivity to aromatase inhibitors

Perioperative ivonescimab with or without chemotherapy in resectable non-small cell lung cancer: a phase 2 trial

From compartments to dynamic physiology: toward actionable body composition

Global health outcomes from replacing dietary sodium chloride with potassium-enriched salt

Mechanical circulatory support in acute myocardial infarction cardiogenic shock: a systematic review and meta-analysis of mortality and safety outcomes

Sedentary behavior and obstructive airway diseases: a narrative review of bidirectional associations, mechanisms, and clinical implications

Whole-blood NAD levels track cardiovascular disease but not chronological age

Cryopreservation of human hair follicles for organ culture

Glucose–steatosis–fibrosis and glycemia–fibrosis scores in relation to mortality in NHANES 1999–2018

Subacute carbon monoxide exposure alters AgNOR number and area ratio in the cerebral cortex of rats

Author Correction: In vivo base editing gene therapy for heterozygous familial hypercholesterolemia: a phase 1 trial

Diagnostic accuracy of transvaginal ultrasound using the IDEA protocol and UBESS staging compared with laparoscopy in deep endometriosis

RELAX: Reliability enhancement by limiting adverse eXertions

MedClassNet: a novel NLP framework for automated disease classification from clinical text using transformer and graph attention networks

Impact of axial length correction on retinal and choroidal thickness by widefield optical coherence tomography

An exploratory remote pilot study of environmental risk factors for Lewy body dementia considering sex differences

A live biotherapeutic product for adult allogeneic hematopoietic cell transplantation recipients: a partially randomized, placebo-controlled phase 1b trial

The convergence of senescence and ferroptosis amplifies DNA damage and triggers apoptosis in patient-derived melanoma models

Exhaustive treadmill run increases urinary excretion of albumin and creatinine but not cell-free DNA in average trained healthy men

A machine-learning model for HFNC failure in older adults with COVID-19 showed inconclusive cross-site performance

Genotype-specific association of dietary chromium intake with type 2 diabetes according to FTO rs9939609: a case–control study

Progress and remaining priorities in geospatial analysis of health inequalities

Genetic insights into foveal morphology and its associations with pigmentation and age-related macular degeneration

DICAM deficiency exacerbates cisplatin-induced acute kidney injury through enhanced oxidative stress, inflammation, and tubular cell death

Heart rate deceleration tracks antidepressant response to accelerated dorsomedial prefrontal intermittent theta-burst stimulation in major depression

Shotgun proteomics differentiates COPD from asthma patients, smokers, and non-smoking controls: a pilot exploratory study

Evaluation of fibrin membrane-embedded adipose-derived mesenchymal stem cells for corneal repair in a rabbit corneal alkali-burn model

RETBind: a patient-level multimodal foundation model for unified cross-modal retinal representation learning

Longitudinal monitoring of tumor physiology following cyclophosphamide treatment using diffuse reflectance spectroscopy and diffuse correlation spectroscopy

Gut microbiome of children with Autism Spectrum Disorder associates with clinical severity

Early postoperative endothelial activation and stress index (EASIX) as a novel biomarker for delirium and mortality after cardiac valve replacement surgery: a retrospective cohort study based on the MIMIC-IV database

Contrast sensitivity, binocular function, and higher-order aberrations after conventional and topography-guided PRK following penetrating keratoplasty

Physical activity, sedentary time, and anthropometric differences in Saudi children with cerebral palsy compared to typically developing peers: an activPAL-based study

Predicting short-term mortality in sepsis-associated acute kidney injury: an explainable machine learning model with a web-based prototype

Nonlinear associations and diagnostic performance of surrogate insulin resistance indices for diabetic retinopathy in type 2 diabetes

Brain-first body-first model translated to individual-level characterization in Parkinson’s disease: multimodal imaging and clinical approach

Effects of physical activity on nontuberculous mycobacterial pulmonary disease incidence and mortality

Fertility trial of single layer centrifugation as an alternative to antibiotics in stallion semen extenders

Vaginal microbiota composition, inflammation, and preterm birth vary by HIV status and ethnicity in a UK pregnancy cohort

Seroprevalence and clinical correlates of fascioliasis among patients with hepatobiliary diseases in Urmia in Northwest Iran

Combing-triggered electrostimulation synchronizing deep delivery for rapid hair regrowth in androgenetic alopecia

Therapist’s views on wearable, asynchronous movement therapy in neurorehabilitation

Seroprevalence and associated risk factors of Trypanosoma evansi in camels in Fafan pastoral areas, eastern Ethiopia

Piperacillin concentrations in bile—a prospective observational study in ERCP patients

Integrative animal model and pilot clinical study reveal the therapeutic effects and mechanisms of Modified Wumei Pill against intestinal inflammation

Disease-specific alterations in plasma fatty acids and arachidonic acid metabolites in ulcerative colitis and crohn’s disease

Decoding the human factor through a multi-dimensional analysis of individual factors contributing to non-fatal crashes

Early albumin infusion is associated with lower mortality in patients with sepsis and concurrent heart failure: a retrospective cohort study

Cost-effectiveness analysis of digital medicine support models for alcohol use disorder

Sustained long-term benefits of structured primary care for patients with coronary artery disease: a 12-year cohort study in Germany (2011–2022)

Vasomechanic treatment is associated with increased efflux of human brain proteins

Effects of nutritionally relevant milk basic protein supplementation during zoledronate treatment in ovariectomized rats

Family history of low back pain is associated with low back pain, lower quality of life, and lumbar MRI findings

Balancing de novo and salvage pathways in cellular nucleotide synthesis

VISTA with subepithelial connective tissue autograft versus fascia lata allograft for multiple gingival recessions: a randomized controlled trial

Hematopoietic loss of KDM6A impairs cardiac recovery in heart failure via epigenetic reprogramming of myeloid cells

Absent vestibular evoked myogenic potentials and graviception cofactors in adults with diabetes

ADAR nonsense variant in a Vietnamese patient with dyschromatosis symmetrica hereditaria

Bone age estimation from lateral cephalograms using cervical vertebrae–centered ROIs: a multicenter deep learning study

Kinematic validation of an IMU-based 2-segment foot model using optical motion capture and the oxford foot model

Outcomes of transplanted organs from donors with cardiac arrest by hanging in a nationwide Japanese cohort

The Genome Atlas of 1,020 Probands and 409 Unaffected Parents Decodes the Clinical Heterogeneity in β-thalassemia

Efficacy and safety of combined oral dutasteride 0.5 mg and minoxidil 2.5 mg versus dutasteride or minoxidil monotherapy in male androgenetic alopecia

Letter in response to “Intramedullary injection of polymerized laminin in acute traumatic spinal cord injury: a first-in-human pilot study1”

Interpretable AI for echocardiography-based early screening of rheumatic heart disease in Ethiopia: a cost-effective strategy to tackle a persistent global health disparity

Molecular mechanism of preoperative autologous blood donation and the modified blood-derived PBMCs preservation solution in improving blood-derived PBMCss in diabetic patients

Staphylococcus aureus and MRSA colonization and antimicrobial susceptibility among neonates, mothers, and the NICU environment in Addis Ababa, Ethiopia

Development and internal validation of survival models for predicting a composite clinical endpoint using clinical variables and quantitative SPECT/CT imaging features

Artificial intelligence readiness in healthcare and health professions education in conflict-affected Syria: an online cross-sectional study

An interpretable machine learning model for identifying coexisting type 2 diabetes in metabolic dysfunction-associated fatty liver disease

Overweight and obesity as predictors of work-related upper extremity disability among dentists in Arak, Iran: a cross-sectional study

Exploration of inactivated bone using high hydrostatic pressurization for future oncologic application

Contrast-enhanced magnetic resonance imaging-based measures of arterial signal-enhancement in patients with peripheral artery disease

Cardiometabolic risk factor burden, psychological symptoms, and immune cardiovascular symptom profiles in adults: a cross-sectional study

Denosumab in multiple myeloma patients with severe renal impairment: a multicenter phase 2 study

Impact of interval between freeze-all retrieval and first frozen embryo transfer: a large retrospective cohort study

Magnetic targeting of autologous bone marrow–derived mesenchymal stromal cells for knee osteoarthritis: a first-in-human exploratory study

Two year randomised trial of twice versus once daily 0.01% atropine for childhood myopia control with real world extension

Combined inflammatory, lipid-accumulation, and pulsatile hemodynamic burden and cardiovascular disease across adapted CKM stages: a CHARLS cohort study

Factors influencing plasma brain-derived neurotrophic factor (BDNF) in adolescent sport participants

Targeting hypersialylation in pancreatic cancer microfluidic models reverses its malignant phenotype and enhances CAR-T therapy

Training-corpus overlap and evaluation protocol constrain measured gains in a fine-tuned clinical language model

Differences in shoulder range of motion among tennis athletes by age and sex

Culture-independent strain typing of Clostridioides difficile in fecal samples

Relationship between serum soluble HLA-G levels and clinico- pathological characteristics of endometrial cancer

Case series of combined microabrasion, home bleaching and resin infiltration for moderate-to-severe dental fluorosis

Population-specific reference equations for fractional exhaled nitric oxide in healthy jordanian adults: a cross-sectional study using GAMLSS

Prolonged visual-motor dual-task effects on dynamic stability in children with ADHD subtypes

Effects of corneal cap thickness on corneal morphological and biomechanical properties of rabbits in vivo following SMILE

Association of admission acid-base phenotypes with delirium in cardiac critical illness: a multicenter cohort study

The Consumer AI and Mental Wellbeing Commission: matching mass adoption with evidence, safety and equity

College graduates and higher income adults in Japan unmasked faster after the government relaxed its mask guidance

Transfer learning enables automated pituitary gland segmentation on brain MRI in 6-year-old children

Randomized trial of pressure controlled versus volume controlled ventilation during robot assisted urological surgery in the clasp knife position

Features influencing diagnostic yield of exome sequencing in the DECIPHERD rare diseases study in Chile

Towards anti-influenza nasal sprays: infection models and opportunities to reduce animal testing

Privacy-preserving deep learning for automated ANB estimation from lateral cephalometric radiographs with an exploratory extension to Cobb angle assessment

Cervical cancer on-site mass-screening device utilizing multiple biomarkers in Swab samples for surveillance in the resource limited areas of India

Predictors of delayed healing after anal fissure surgery: association of Helicobacter pylori infection and intestinal parasitic infestations with healing outcomes—an observational study

Neoadjuvant botensilimab with or without balstilimab in pMMR and dMMR colon cancer: the phase 2 UNICORN trial

Povorcitinib for nonsegmental vitiligo: two randomized, controlled, phase 3 STOP-V trials

The safety and efficacy of oral vitamin C administration on erythropoietin dosing requirements in end stage renal disease patients on regular hemodialysis

Healthcare utilization and costs associated with structured oncological training therapy: a retrospective analysis in cancer patients

Metabolomics-based central obesity identifies subtypes musculoskeletal disorders management

Challenges and innovations in cardiac AAV gene delivery as a platform for cardiac regeneration

Neoadjuvant concurrent or sequential anthracycline-containing chemotherapy and HER2-targeted agents for HER2-positive breast cancer: a randomized phase 2 study (METIS)

Comparative efficacy and safety of pharmacological interventions for postmenopausal osteoporosis: a network meta-analysis

Real-time XR-based 6-DOF catheter tracking enhances cardiac intervention navigation efficiency and depth perception

Changes in breast cancer management and care infrastructure in Turki̇ye: a ten-year multicenter comparison, 2009–2019

Development and external validation of a predictive model for epithelial ovarian tumors based on MRI features and serum tumor markers

Serial multi‑time‑point assessments of well‑defined somatosensory domains and their associations with limb spasticity after ischemic stroke

Development and validation of a nomogram for screening poor sleep quality among night-shift nurses

Evaluation of large language models’ responses to patient questions about avascular necrosis of the femoral head

Community-based RoboGym training improves gross motor function in ambulatory children with cerebral palsy

Metabolic reprogramming modulates cardiomyocyte hypertrophy via GLS1 in chronic kidney disease in male mice

Effects of fiber post and restoration type on endodontically treated maxillary premolars: finite element analysis and in vitro study

Surveillance epidemiology and an open machine-learning benchmark of antimicrobial-resistant healthcare-associated infections in a Chinese district hospital

Intelligent clinical decision support system for intracranial aneurysm lesion-based detection using biomedical imaging data

Sleep disturbances and their association with quality of life and depressive symptoms among elderly residents of long-term care facilities: a cross-sectional study

Healthy diets and heart rate variability in a cross-sectional analysis of over 7000 adults attending the Maastricht study

[Editorial] Improving men's health in a changing world

Many men are failing to thrive. Shorter life expectancies for men than for woman first emerged in the 19th century and the gap has continued to widen (albeit w…

[Comment] From PROSpect to the bedside: contextual and pathophysiological considerations

Paediatric acute respiratory distress syndrome (PARDS) is a common, severe manifestation of direct or indirect lung injury in children. Management focuses on t…

[Comment] Non-invasive tests in MASH: clinical practice versus trials

Non-invasive tests (NITs) are central to clinical decision making in metabolic dysfunction-associated steatotic liver disease, including risk stratification, t…

[Comment] Men's health: recognising and responding to the problems

The authors of The Lancet's Series on men's health1–3 provide a genuinely world-scale picture of the issues. Their approach links biological with social proces…

[Comment] Offline: Seizing new opportunities for climate and health

The Lancet Countdown on health and climate change celebrated its tenth anniversary this week. The Countdown was preceded by two Lancet Commissions that sought…

[World Report] Health-care costs could help decide US midterm elections

With an opportunity to overturn Republican control of Congress, Democrats hope to win voters’ support by focusing on cuts to health-care programmes. Susan Jaff…

[World Report] Wild polio cases rise in Afghanistan

Afghanistan has reported twice as many polio cases than in 2025, prompting concern over the Taliban's vaccination policies. Samaan Lateef reports.

[World Report] First human case of Shamonda virus recorded

A patient in France has died from the infection, which normally affects cattle. Virologists say the wider risk to public health is low. Marianne Guenot reports.

[Perspectives] Derek Griffith: transformative leader in men's health

“We know a lot about male health. We don’t know a lot about men's health”, says Derek Griffith, who is one of the authors of a new Lancet Series on men's healt…

[Perspectives] James W Catto: tackling the inequalities in men's health

Jim Catto, co-leading author of the Lancet Series on men's health, was reluctant to be the subject of a profile, insisting it is more important to highlight wh…

[Perspectives] Aid cuts and the slow death of a rural lifeline

On my tenth visit, it took me two attempts to find the care and treatment centre (CTC) for people living with HIV/AIDS in Miono, Tanzania. The one-storey white…

[Obituary] Paul Veys

Pioneer of paediatric stem cell transplantation and Director of the Bone Marrow Transplant Unit at Great Ormond Street Hospital for Children, UK. Born in Dar e…

[Correspondence] Lessons from the WHO South-East Asia Regional Director debacle

Saima Wazed, the Regional Director for WHO's South-East Asia Regional Office, resigned in September, 2026.1 Wazed's appointment drew considerable public attent…

[Correspondence] Whose vitiligo goes untreated?

The Lancet Editorial1 on skin diseases rightly argues that vitiligo trials such as Viti-Up, in which more than 70% of participants were White, should enrol pat…

[Correspondence] Global health reform: a suggestion

Having worked for WHO for 5 years at the end of a career as an academic in global health, I was keen to read Richard Horton's Offline on the tragic fallacy of…

[Correspondence] Mahler, polycrisis, and the next Director-General of WHO

In his recent Offline on the upcoming elections for the new Director-General of WHO,1 Richard Horton mentions several of the previous Director-Generals, starti…

[Articles] Prone positioning and high-frequency oscillatory ventilation in early paediatric acute respiratory distress syndrome (PROSpect): an international, two-by-two factorial, response-adaptive, phase 3, randomised controlled trial

We found no evidence to support prone positioning or HFOV as first-line strategies to improve ventilator-free days in patients with early, moderate-to-severe P…

[Articles] Non-invasive tests in metabolic dysfunction-associated steatotic liver disease: the LITMUS prospective multicentre diagnostic accuracy study

Although single markers resulted in variable and limited performance when compared to histology for detecting at-risk MASH, multimarker panels showed great pot…

[Series] Men's health: an intersectional and multilevel framework for understanding syndemic patterns of health

Men occupy a privileged position within gender power relations: the male body has been the default reference point for biomedical research and therapeutic deve…

[Series] A global men's health epidemiology within an intersectional framework

Males have lower life expectancies and greater disability-adjusted life-years (DALYs) than females, and particularly poor outcomes are seen among males in marg…

[Series] Charting a course to men's health and wellbeing: applying a lens of power and politics to improve men's health outcomes

Despite long-standing evidence of poor health and life expectancy outcomes among men, particularly among men who are socially or structurally marginalised, men…

[Viewpoint] Reframing the manosphere: a public health response to a commercial ecosystem

The manosphere, a diffuse commercial ecosystem and loose collection of online communities united by shared beliefs about masculinity, misogyny, and male victim…

Defining clinically relevant risk threshold for predicting sudden cardiac death

Prior institutional contact and hospitalization risk after telemedicine visits for acute respiratory infections

Generation of synthetic clinical text: a systematic review

Dosimetric evaluation and energy optimization in proton therapy for Hodgkin’s lymphoma using a GATE-based Monte Carlo framework

Menstrual tracking app use in menstrual health management: a cross-sectional survey of user concerns, goals, and strategies

Agreement between pelvic floor muscle assessment methods in women with stress urinary incontinence: a cross-sectional study

Standard and decoupled knowledge distillation for lightweight radiographic knee osteoarthritis grading and triage

A hybrid bio-inspired optimization framework for modeling infant neurodevelopment from maternal mental health and biometric data

A harmonised protocol for generating human extracorporeal photopheresates for research

Pre-transplant cardiovascular risks and adverse outcomes in patients after receiving kidney transplantation

A pilot study on individual differences in humor style and their associations with self-rated physical health and blood pressure

Timing of vancomycin initiation and mortality in critically Ill patients with sepsis and type 2 diabetes: A clone–censor–weighting analysis

Changes in adaptive behavior, gut microbiota and fecal metabolites following an integrative intervention in children with autism spectrum disorder

Pembrolizumab plus paclitaxel with optional bevacizumab for platinum-resistant recurrent ovarian cancer with PD-L1 CPS ≥ 1: a cost-effectiveness analysis

The growing burden of diabetes mellitus in Ethiopia: a systematic review and meta-analysis

Morphometric changes in foramen rotundum before adulthood: a CT study

A multimodal characterization of early monoarthritis in rats using an MBSA/CFA-induced model

Neutrophil-to-lymphocyte ratio as a low-cost triage marker for malaria in febrile patients in conflict-affected Southern Yemen

Assessing the reliability of accelerated quantitative susceptibility mapping sequences in memory clinic patients

Castor oil plus sweeping membrane maneuver versus oral misoprostol for labor induction: a prospective observational study

Estimated fat mass and body mass index z-score in relation to locomotion-related components of physical fitness in Japanese elementary schoolchildren

Shared genetic architecture across fibrotic diseases

Salivary and blood measurement of hs-cTnI and an adipokine panel in acute myocardial infarction: an exploratory paired-matrix study

Targeting DKC1-mediated pseudouridylation combined with PARPi induces synthetic lethality in homologous recombination-proficient tumors

Principles for a patient-centred transition to low-global warming potential pressurised metered-dose inhalers

Reversal of trauma-induced monocyte paralysis by IFN-γ fails to prevent ventilator-associated pneumonia, implicating lymphoid deficits in infection risk

Extracellular matrix in dental pulp and dentin regeneration: from compositional and mechanical cues to scaffold-based translational strategies

Disease continuum of seronegative rheumatoid arthritis: from development to prevention, from management to disease resolution

Validating therapy decisions by reasons for therapy switch in relapsing-remitting multiple sclerosis

Predicting persistent fever in patients with cancer receiving antibiotics: a machine learning approach

Performance of the DxI 9000 Access immunoassay analyzer for the diagnosis of viral hepatitis B and C

Caffeine-related exposure and dry eye disease: a systematic review and meta-analysis of epidemiological associations and tear-related outcomes

Thymus zygis essential oil-loaded bacterial cellulose as an antimicrobial and antibiofilm biomaterial: an in vitro study

Head stabilization patterns reflect long-term postural stability alterations during gait associated with history of concussion

Transformer language models reveal distinct patterns in aphasia subtypes and longitudinal change

Latent-aligned scalable interpolant transformer for controllable chest X-ray synthesis

Accuracy and impact of an AI safety system for missed specialist referrals in primary care

Mobile health application for adherence and symptom management in hemodialysis patients: a randomized controlled trial

Ethical challenges in patient-focused drug development for rare genetic diseases

A haplotype reference panel constructed from 490,319 UK Biobank genomes improves genotype imputation for global populations

Attitudes to genetic testing and reproductive interventions among patients with inherited retinal disease in Singapore

Inflammatory biomarkers, stroke severity, and 1-month outcomes in minor acute ischaemic stroke by small-vessel occlusion status

Molecular characterization of hepatitis B and hepatitis delta viruses in Mauritanian HBV chronically infected patients

RehaBot: a user-centered design and usability evaluation of a chatbot-based platform for cerebral palsy telerehabilitation

Performance of artificial intelligence-assisted cytology and high-risk human papillomavirus testing for cervical cancer screening

Age-dependent threshold effect of reproductive lifespan on cardiovascular disease in chinese women: a CHARLS cohort study

Fibroblast activation protein mediates vascular restenosis after surgery for peripheral arterial disease

Deep learning classification of longitudinally defined 24-2 central- and peripheral-onset visual field phenotypes in glaucoma using baseline fundus photographs

Design and pilot usability study of a mobile self-care application supporting physical activity among low-risk pregnant women

A Markov transition analysis to study changes in HIV prevention strategies among men who have sex with men in the French ANRS-PREVENIR cohort

Comparison of subjective orofacial esthetic perception and objective malocclusion severity: a cross-sectional study

Severe vitamin D deficiency among pregnant women delivering at a governmental hospital in Nablus, West Bank, Palestine: a cross-sectional study

A rapid multiplex LC-MS/MS platform for simultaneous monitoring of eight antibiotics: clinical application and exploratory analysis of determinants of personalized dosing in critically ill patients

Development and validation of a risk score to predict mortality in the pediatric intensive care unit using routinely collected data in Northwest Ethiopia: a retrospective study

Biomarkers of cellular senescence and their association with frailty, clinical outcomes, and survival in multiple myeloma

Eye-state-dependent reorganization of EEG microstates in a pediatric transdiagnostic cohort

Influence of different methods of sealer agitation on the quality of root canal obturation: a micro-CT study

Clinical and molecular characteristics of FLT3-ITD microclones in elderly patients with acute myeloid leukemia receiving less-intensive therapy

One Health genomic surveillance identifies potential genetic links of antimicrobial-resistant foodborne pathogens across sectors

Recognising the first visible signs of leprosy and late case detection in a low endemic area of Benin

Evaluation of an extracurricular undergraduate ultrasound training program at a central European medical faculty

Antimicrobial effectiveness of passive ultrasonic irrigation following preparation with single-file and multi-file NiTi instrumentation systems in flattened root canals

Cultural adaptation and validation of Eye Frailty Self-Check List for middle-aged and older adult in China

The association between preceding birth interval and childhood stunting in Benin

Longitudinal blood-based proteomics reveal progression-specific molecular signatures in Parkinson’s disease

Magnoflorine alleviates experimental osteoarthritis and is associated with altered M1- and M2-associated macrophage markers and subchondral bone remodeling

Serological and molecular evidence of an endemic presence of mpox and associated risk factors in semi-rural areas of southern Cameroon

Establishing a normative model for turbulence dynamics in the brain

Maternal and neonatal outcomes after French Ambulatory Cesarean Section (FAUCS): a prospective study

Six test exercises to assess weaknesses in four physical abilities related to fall risk

Dentists’ acceptance of artificial intelligence-assisted decision support for oral potentially malignant disorder detection: a structural equation modeling study

Vaccination rates, facilitators and barriers for influenza, pneumococcal and SARS-CoV-2 vaccination among sepsis survivors: a Mid-German Sepsis Cohort survey

A matched-cohort study of treatment-requiring autoimmune rheumatic diseases after COVID-19

Temporal changes in quadriceps tendon mechanical properties following anterior cruciate ligament reconstruction: an in vivo shear wave elastography study

Niosomal in situ gel enhances the ocular bioavailability of kaempferol and improves therapeutic efficacy in dry eye disease

Platform evaluation and lessons learned with IT-supported patient recruitment

A small-molecule TREM2 agonist for Alzheimer’s disease

Applying digital twins to prevent preterm births

M6A demethylation of IRF9 by ALKBH5 promotes intervertebral disc degeneration via nucleus pulposus cell necroptosis

Genetic insights into IgA vasculitis pathogenesis

Estimation of lip position from alveolar ridge measurements using sex- and age-specific regression models in a Korean population

Development and validation of an artificial intelligence model for automated classification of whole-body bone scintigraphy in oncology patients

Predicting the number of infant deaths per woman in ethiopia using complementary count regression and machine learning approaches

An exploratory retrospective study of low bone density and perioperative D-dimer and Wells score after unicompartmental knee arthroplasty

Effects of an 8-week game-based corrective exercise program on dynamic balance and postural alignment in girls with hearing impairment: a randomized controlled trial

Clinical risk factors alone do not predict the development of moderate-severe chronic graft-versus-host disease after hematopoietic cell transplantation and post-transplant cyclophosphamide

Evaluation of housekeeping gene stability in placental tissues: comparative expression studies in first-trimester, preeclamptic and control placenta

Interpretable prediction of in-hospital venous thromboembolism in critically ill patients with heart failure receiving early thromboprophylaxis

Association of glycemic variability with delirium and mortality in critically ill patients with community-acquired pneumonia: a retrospective analysis

A proof-of-concept study on molecular fluorescence spectroscopy (EEM) combined with chemometrics applied to screening for autism spectrum disorder

Systemic Inflammatory markers are associated with drug-resistant pediatric epilepsy in Ghanaian children

High stimulation rate ABR reveals auditory brainstem conduction abnormalities in vestibular migraine

Hemostatic efficacy and safety of oxidized regenerated cellulose hemostatic material in a multi-organ bleeding porcine model

Gender affirmation concerns of aging transgender women: findings from qualitative listening sessions

Time to uptake of long-term postpartum family planning and factors associated with it among Ethiopian mothers: A shared frailty survival analysis

Endotracheal application of Ultraviolet A light in Pseudomonas aeruginosa ventilator-associated pneumonia: a sham-controlled large animal study

The spirometric blind spot: oscillometry identifies a tobacco-dose-associated small-airway signal in community case-finding

Prevalence of drug-related hospital admissions and associated factors among chronic internal medicine wards in Wolaita Sodo University Comprehensive Specialized Hospital

Quality and readability of large language model–generated responses on type 2 diabetes remission: a cross-sectional balanced factorial study

Mechanism by which NCOA4 promotes osteoarthritis progression through iron overload-induced mitochondrial dysfunction in chondrocytes

Normative OCT-derived ocular measurements in rhesus macaques

CXRG-SVLM: a parameter-efficient small vision-language model for multi-view chest X-ray report generation in resource-constrained environments

Optimal closed-loop feedback control of blood flow after spinal cord injury with norepinephrine

Perfusion-guided virtual element analysis for biomechanical diagnosis of breast cysts and tumors

The gut–muscle–joint axis in osteoarthritis: Mechanistic insights and therapeutic perspectives

Sex- and frequency-dependent acute pharmacokinetic and pharmacodynamic effects of smoked cannabis: a randomized controlled trial

Changes in circulating biomarkers in symptomatic atrial fibrillation from before to one day after catheter ablation

Diurnal variation of islet autoantibody titers in established type 1 diabetes suggests restricted-time sampling improves aab measurement and detection

5-year outcomes of chemotherapy de-escalation in HER2-positive early breast cancer and exploratory circulating tumor DNA analyses from the randomized phase 2 PHERGain trial

Metabolic sensor Gpr35 links dietary lipids to itch mediating neural circuits

A clinical multimodal vision language foundation model with fine-grain explainability

Validation of a deep neural network workflow for fully automated dicentric chromosome analysis in biological dosimetry

A study to explore the physiological impact of AIR+ KN95 masks on children

Evaluation of the feasibility of classifying various upper limb movements using multichannel upper-arm sEMG signals

Comparison of restorative materials on masticatory function and gingival crevicular fluid inflammatory factors in tooth defect patients

A physics-informed peripheral hemodynamic digital twin for personalized estimation of arterial stiffness

Association between sample entropy and cardiorespiratory events in preterm infants routinely immunized in the hospital

Correlation of optical coherence tomography and histology in a laser-induced mouse retinal injury model

Governing accelerated evidence in real-time clinical trials

Factors influencing medical students’ adoption of digital therapeutics: a cross-sectional study using FsQCA

Beyond food waste reduction: nutritional contributions of food rescue initiatives. A systematic review

Lifetime economic impact of pediatric cataract surgery in sub-Saharan Africa: a case study from Kinshasa

Paraspinal mechanical muscle activity assessment during gait in adolescent idiopathic scoliosis using mechanomyography

Resting-state electroencephalographic characteristics in patients with atopic dermatitis accompanied by chronic pruritus

TNF-induced lethality occurs independently of NLRP3 inflammasome signaling

Impression-R1 for radiological impression generation with multicenter benchmarking and prospective evaluations

Key considerations from intrinsic properties to context-dependent performance in the preclinical evaluation of crosslinked HA dermal fillers

Rotational behaviour and morphological associations of the CT-based distal ulnar centering and eccentricity (DUCE) method in cadaveric specimens

Long-term EQ-5D outcomes in sepsis survivors after ICU discharge: a systematic review and meta-analysis

Comparative effects of supervised aerobic and combined training with dietary counseling on metabolic biomarkers in sedentary adult male bank employees: a randomized controlled trial

Management of androgen deprivation therapy-related adverse effects and supportive care: a survey among Italian radiation oncologists

Safety and guideline concordance of public large language model responses to patient-facing questions on active charcot neuro-osteoarthropathy

Prevalence of anaemia and Associated Factors among pregnant women attending antenatal care in a rural district of Northern Ghana: a cross-sectional study

Changes in patients’ quality of life during hyperbaric oxygen therapy: a repeated-measures pre-post study

Association of antibiotic exposure with Kawasaki disease

Knowledge, perceptions, and associated factors of marburg virus disease in selected towns and districts of the South Ethiopia Region: an explanatory sequential mixed-methods study

Association between long-term ozone exposure and kidney function among Thai adult workers in the EGAT cohort study

Mental health and socioeconomic determinants of suicide risk among people living with HIV in Taiwan: an 18-year national cohort study

Enlarged brain perivascular spaces in chronic schizophrenia but not in first-episode psychosis: a cross-sectional study

Shared genetic architecture between adhesive capsulitis and type 2 diabetes: a phenotype-specific cross-trait analysis

Analysis of the proteomic profiles in serum of mice treated with RadioDefender, a novel radiation medical countermeasure

Health literacy and preventive behaviors against PM2.5 exposure among residents in a Thai Province: a cross-sectional study

A machine learning-based predictive model for gestational diabetes mellitus based on first trimester clinical indicators

Leveraging biased FedSDS as a federated learning strategy for research on non-IID multi-disorder studies

Effects of video reinforcement following face-to-face CPR/AED training on knowledge, attitude, and simulated performance among frontline community workers: a quasi-experimental study with post-training randomized allocation

Association of ABO blood-group phenotype with postoperative bleeding and long-term mortality after coronary artery bypass grafting

Classification model for LESS-defined bilateral jump-landing patterns based on XGBoost–SHAP and analysis under cognitive dual-task conditions

Adjunctive iliac vein stenting for May-Thurner-associated lower-extremity phlebolymphedema: a dual-center retrospective cohort study

COVID-19-associated pulmonary aspergillosis: clinical characteristics, species distribution, environmental fungal contamination, and antifungal susceptibility

Evaluation of explainable artificial intelligence for subarachnoid hemorrhage detection and outcome modelling using neuroimaging data

Using artificial intelligence for clinical trial quality assurance in a multi-institutional neurovascular-sparing prostate radiotherapy trial

Serum brain-derived neurotrophic factor response to maximal exercise in coronary artery disease and chronic heart failure

Salivary microbiome-based classification of concordant intra-oral halitosis: Porphyromonas gingivalis as a candidate sentinel taxon

Health risks of hot and cold temperatures in people with pre-existing conditions and social disadvantage

A preliminary study on wound healing and scar reduction using platelet-rich fibrin matrix

Ginsenoside Rb1 alleviates uterine aging via AMPK-mediated mTOR inactivation

Ameliorating effects and mechanisms of therapeutic electrical stimulation on the recurrent laryngeal nerve injury model in rats

Long COVID burden in healthcare workers: a 12-month survey of 771 cases

Birth weight, cognitive reserve and outcomes after first-episode psychosis

Color matching ability of single-shade resin-based composites: an in vitro study

Micro-CT analysis of the maxillo–lacrimal complex in Plecotus auritus (Linnaeus, 1758) and description of the processus intersuturalis maxillo–lacrimalis (nova structura)

Radiographer fracture detection with and without AI assistance in prospective emergency department use

General-purpose AI as a source of mental health support amongst 24,000 adolescents in England

A sequential dose-finding study of fentanyl during remimazolam induction for tracheal intubation in adults

Neoadjuvant apalutamide for high-risk prostate cancer

Model selection in linear mixed-effects analysis of craving outcomes in a randomized controlled trial of medications for opioid use disorders

An interpretable graph reasoning framework for enhanced diagnosis in fundus fluorescein angiography

Gene therapy that led to boy’s death had limited efficacy

Lipid profile and treatment results in adults aged 25–64 in Czechia: a cross-sectional study

[18F]FDG brain PET-MR versus PET/CT in a clinical cohort: intra-subject quantitative comparisons

A generalizable pipeline for specialty-curated postmarket device surveillance: a reference implementation in neurosurgery

Feasibility assessment of novel binocular eye alignment monitor device for intermittent exotropia

Performance of artificial intelligence for fracture detection: an umbrella review and second-order-meta-analysis

Patterns of cardiovascular-kidney-metabolic (CKM) syndrome stages and prevalence of lifestyle risk factors in a nationally representative iranian population study

Spatial profiling of extramedullary multiple myeloma demonstrates immune-excluded and suppressive tumor microenvironment

Scalable drift monitoring in medical imaging AI

Plasma retinol binding protein 4 improves survival of Klebsiella pneumoniae-induced pneumosepsis through stimulation of neutrophils

Viral etiology and predictors of hospitalization in adults younger than 65 years with laboratory-confirmed respiratory viral infections in the pre-COVID era

Evaluating the real-world accessibility of open-source deep learning models for retinal vessel segmentation in optical coherence tomography angiography

Preoperative GLP-1 receptor agonist use is associated with lower 2-year emergency department utilization and all-cause mortality after total shoulder arthroplasty

Complementary medicine awareness, beliefs, and recent conventional CAM use among university students with and without self-reported previous physician-diagnosed IBS in Palestine

Mobile application-based digital therapeutics for frozen shoulder rehabilitation: a single-center, randomized controlled pilot study

Fourier multiscale analysis of bilateral breast asymmetry associated with breast cancer

Triglyceride-glucose index combined with DAS28-ESR predicts cardiovascular disease risk in patients with rheumatoid arthritis: a national multicenter cohort study

Genomic and phenotypic characterization of the Jeju Genome Project cohort in Korea

Vital sign analysis and correlation of physiological parameters using edge AI and IoT technology

Investigation on the preventive effects of total flavonoids extract from Ziziphi Spinosae Semen on depression and associated liver injury

Standardizing in-hospital cause-of-death data using large language models and neural machine translation

Quality, reliability, and accountability of patellofemoral pain-related short videos on three Chinese social media platforms: a cross-sectional comparative study

Increasing dengue outbreaks in temperate Brazil are associated with Aedes aegypti invasion and infestation levels

Investigating the effects of dexmedetomidine in cecal ligation and puncture‑induced septic rats

Author Correction: Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial

Predicting 1-year outcomes after anterior cruciate ligament reconstruction from preoperative physical performance using machine learning: an exploratory study

Feasibility and safety of stand-alone stent retriever thrombectomy for acute embolic mesenteric ischemia in a canine model

Knowledge, attitudes, and physician engagement among hospitalized older adults using long-term sedative-hypnotics

Tissue and plasma expression patterns and bioinformatic analysis of miR-15a-5p, miR-145-5p, miR-221-3p, and miR-455-3p in primary pterygium

The Gujarat Tribal Genome Project (2kTGP)

Vaccine handling practices and determinants in immunization centers of Gambella, Ethiopia: a cross-sectional study

Anatomy-guided U-Net deep learning for sparse-view chest CT reconstruction using spatially varying RTV regularization

Automated segmentation and quantification of histological liver features for MASH/MASLD scoring

PVminerLLM: structured extraction of patient voice from patient-generated text using large language models

FHIRconnect: towards a seamless integration of openEHR and FHIR

Untargeted metabolomics reveals a reproducible signature associated with fatal insulin intoxication

Development of cinnarizine nanoemulsion for enhanced topical delivery with ex vivo permeation and in vivo pharmacodynamic evaluation

Single-cell landscape of human adipose tissue reveals THBS1 as a potential driver of fibro-inflammation in metabolic disease

FLAT-WHITE: from target trial emulation to federated high-throughput causal machine learning using decentralized real-world data

Factor structure of the Community Screening Interview for Dementia (CSI-D) among Zambian adults

Author Correction: A decoupling strategy toward spatiotemporal regulation and biomechanical transmission of sandwiched scaffold for osteochondral regeneration

Publisher Correction: Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health

Midkine as a context-dependent molecular rheostat in tissue regeneration and aging

The 3’UTR protects bone against menopause-induced osteoporosis via regulating CHD9 expression

AI chatbots showed higher response accuracy than dentists, medical doctors, and the general public on radiation safety questions

Hybrid retrieval–verification framework for hallucination reduction in medical LLMs

Temporal trends in hypersensitivity pneumonitis–coded mortality: a multinational analysis of 32 countries, 1999–2019

First-day Braden score carries more prognostic information than vasoactive dose for pressure injury in ICU patients receiving early vasoactive support

Systemwide adoption patterns of ambient AI scribe technology in an integrated academic health system

Temporal trends and clinical factors associated with ketamine infusion in hospitalized infants with bronchopulmonary dysplasia

Altered integrin αvβ3 and extracellular matrix-associated molecular profile in granulosa cells from women with polycystic ovary syndrome

Cytomorphological assessment of buccal mucosal epithelial cells in Sudanese children with sickle cell anaemia: a pilot case-control study

Comparative micro-computed tomography assessment of left-sided septal pouch and left atrial appendage morphometry

Causal landscape of the circulating proteome in systemic iron overload revealed by Mendelian randomization and experimental validation

A double diamond model-based design and evaluation method for medical transfer beds

Accuracy of guided endodontic access evaluated through a fully digital workflow with three-dimensional vector-based measurement: an in vitro study

Regulatory T cell instability facilitates blood–brain barrier disruption via the β-catenin-tight junctions axis, leading to perioperative neurocognitive disorders

Association of KCNJ11 and TCF7L2 genetic variants with type 2 diabetes in a Mexican region with high disease prevalence and strong Mayan cultural heritage

Hypertension prevalence and risk factors in a retained high-risk cohort of rural Black adults: a five-year follow-up study in Limpopo Province, South Africa

Dietary AAA/BCAA ratio and glycemic load are associated with obesity and novel anthropometric indices in Iranian adults

Sport-specific differences in DXA-derived bone outcomes persist after adjustment for lean mass in competitive female athletes

Machine learning model for predicting regional lymph node metastasis in acral melanoma

Admission-time prediction of hospital length of stay in diverticular disease using explainable machine learning models

Decision-support modelling for liver paired exchange integrating clinical thresholds and operational feasibility

Multicentre benchmark of PSMA PET/CT and mpMRI fusion for non-invasive clinically significant prostate cancer diagnosis

A stethoscope woven into fabric

Machine learning in predicting recurrence of self-inflicted neck trauma in young adults

Association of dietary total antioxidant capacity, dietary inflammatory index, and dietary phytochemical index with sarcopenia in middle-aged and older Iranian women: a case-control study

Exposure to organochlorine pesticides via breastmilk and infant length-for-age in a cross-sectional study in the Lake Atitlán watershed, Guatemala

Multi-omics liquid biopsy identifies mitochondrial dysfunction in geographic atrophy and supports intraocular bioavailability of α-ketoglutarate

Effect of guideline-assisted prompting on large language model performance in medication-related osteonecrosis of the jaw–related endodontic decision-making

Retinal layer thickness prediction from smartphone fundus imaging for early glaucoma detection

Interpretable machine learning models for oncotypedDX® prediction using clinicopathologic data: a brazilian cohort study

Association of salivary function with oral health-related quality of life in patients with type 2 diabetes and xerostomia: cross-sectional study

Platelet-engineered AAV silencing of myocardial CD36 reprograms fatty acid metabolism to promote cardiac regeneration in male mice

Association of fetal activity patterns in utero with postnatal sleep behavior

Unsupervised ensemble methods for non-wear detection from triaxial accelerometer data in children following continuous monitoring

Self-reported workplace heat and cold exposure time and WHO-5 screen-positive depressive symptoms among Korean employees: a nationwide cross-sectional study

The concept of temporary myopic traction maculopathy resolution after vitrectomy: A multicentre case series and long-term follow-up of 5 patients

Effect of capillary refill time-guided resuscitation on early fluid administration and fluid balance in septic shock: a single-center randomized controlled trial

A pilot cohort study of blood brain barrier permeability in Alzheimer’s disease using dynamic contrast enhanced magnetic resonance imaging

Development of a concise objective biometric triage model for identifying myopia defined by cycloplegic refraction in school-aged children

Development and validation of an interpretable machine learning model for early prediction of refractory mycoplasma pneumoniae pneumonia: a multi-center study

BMI–hepatic steatosis phenotypes and prevalent carotid plaque: a cross-sectional health examination study

ABCC2 rs2273697, rs717620, rs3740066 polymorphisms and antiseizure medication resistance: a systematic review and meta-analysis

Age at type 2 diabetes onset, retinol binding protein 4 and risks of diabetic retinopathy: a real-world cross-sectional study

Morphological and permeability changes of the intestine in patients nourished exclusively with parenteral nutrition: a systematic review and meta-analysis

Reference intervals for neutrophil reactive oxygen species production capacity in Japanese adults

Large language models show product name convergence in drug recommendations

Lactylation-driven mitochondrial dysfunction promotes diabetic myocardial fibrosis via impairing mitophagy and activating TGF-β1

Interpretable machine learning for predicting intraoperative oxygenation impairment during one-lung ventilation in thoracic surgery: a retrospective cohort study

Renal hyperfiltration dynamics as a cardiovascular risk stratification marker

Contrast-enhanced ultrasound in assessment of testicular injury based on different degrees of testicular torsion in rabbits

Effects of vertebral shortening during corrective osteotomy for spinal deformity on spinal cord biomechanics and cerebrospinal fluid-anterior spinal artery fluid-structure interaction

Matrigel scaffold, alone or with human placenta-derived mesenchymal stromal cells, improves histological repair of murine excisional wounds

In vitro evaluation of the osteogenic associated cellular response and antibacterial activities of Vitex negundo leaf aqueous extract

Deep-learning-based electrode action potential mapping from annotation-free unipolar electrograms for substrate characterization in atrial fibrillation

Herpes zoster and major vascular events in a general population without prior cardiovascular event from Shizuoka Kokuho database

Neonatal bilirubin trajectory phenotypes and composite adverse outcomes: a two-database latent-class analysis (MIMIC-III and PIC)

Impact of access cavity design on the filling ability of two obturation protocols evaluated by micro-computed tomography

Depressive symptoms increase during follow-up and are associated with phenoconversion in isolated REM sleep behavior disorder

Human dignity and its associations with self efficacy and treatment adherence in adults with type 2 diabetes in Iran

Foot-specific health status in a large convenience sample of adults living in Spain: a cross-sectional study

Association of MALAT1 and TUG1 transcript levels and cardiometabolic diseases according to cholesterol saturated fat index

The relationship between genetic bone mineral density and spinal stenosis: a Mendelian randomization and cohort study

Micro-CT-informed Monte Carlo and experimental dosimetry of transcranial photobiomodulation devices

Contributing factors for surgically treated Hallux Valgus: a nationwide population-based cohort study in Taiwan

Theratyping for personalized medicine across cystic fibrosis disease models

[Comment] Mitapivat in the RISE UP trial: a new therapy for sickle cell disease

Sickle cell disease is the most common haemoglobinopathy, affecting more than 7 million people worldwide.1 Despite substantial morbidity and mortality, access…

[Comment] Offline: Berlin diary

“WHO is a retirement home…We must reinvent multilateralism…We must be more candid with one another…We do not spend enough time talking with people who totally…

[World Report] Warnings over Ukraine maternity care

Russia's invasion and continued conflict have damaged facilities and led to workforce shortages. Ed Holt reports.

[World Report] Latvian alcohol control policies reducing harms

Latvia has one of the world's highest rates of alcohol consumption but recent policy changes are starting to lessen direct harms to health. Ed Holt reports.

[Perspectives] A guide to anti-racist medicine

Far-right movements in many countries are fuelling xenophobia and racism and gaining traction through policy and media. By conflating equity with equality in t…

[Perspectives] Wisdom and tenderness

In the wake of the COVID-19 pandemic, the widespread mental health toll of the pandemic was quickly appreciated by communities, educators, and health-care prov…

[Perspectives] Longevity is a political concern

Having immersed myself in death and dying for well over a decade—I wrote a book, The Way We Die Now (2016), and was later a member of the Lancet Commission on…

[Obituary] Khairul Islam

Public health doctor and sanitation pioneer. Born on June 25, 1959, in Tangail, in what is now Bangladesh, he died from a cardiac arrest in Dhaka, Bangladesh,…

[Correspondence] Communication: the missing pillar of clinical trial governance

On Sept 2, 2026, negative results of the phase 3 ASPIRE trial (NCT06617429) of apazunersen in Angelman syndrome were announced in a press release issued after…

[Correspondence] Nephromegaly-driven malnutrition in autosomal dominant polycystic kidney disease

We read with great interest the Review by Albert C M Ong and colleagues1 on autosomal dominant polycystic kidney disease (ADPKD), which we regard as an importa…

[Correspondence] Nephromegaly-driven malnutrition in autosomal dominant polycystic kidney disease – Authors’ reply

We thank Matteo Brambilla Pisoni and colleagues for highlighting the importance of nutritional assessment in autosomal dominant polycystic kidney disease (ADPK…

[Correspondence] Beyond imaging thresholds in large-core stroke thrombectomy

Amrou Sarraj and colleagues reported an important individual patient data meta-analysis regarding endovascular thrombectomy (EVT) in patients with large-core i…

[Correspondence] Beyond imaging thresholds in large-core stroke thrombectomy – Authors’ reply

We thank Jordan Bakhriansyah and colleagues for their thoughtful commentary on our manuscript from the ATLAS individual patient data meta-analysis.1 Although t…

[Correspondence] Unanswered questions from the NIMBLE trial

Tuan Vu and colleagues reported that cemdisiran monotherapy (76·6% mean reduction from baseline in total complement haemolysis activity [CH50] inhibition) and…

[Correspondence] Unanswered questions from the NIMBLE trial – Authors’ reply

Xiaohua Tao raises three questions about the interpretation of the NIMBLE findings.1 We welcome the exchange and believe the study findings support the interpr…

[Department of Error] Department of Error

Maure-Blesa L, Carmona-Iragui M, Barroeta I, et al. Natural history and clinical impact of epilepsy in adults with Down syndrome: a multicentre clinical study.…

[Department of Error] Department of Error

Mora P, Aroda VR, Asong M, et al. Efficacy and safety of once-daily oral zenagamtide, a novel unimolecular GLP-1 and amylin receptor agonist, in adults with ty…

[Department of Error] Department of Error

NCD Risk Factor Collaboration (NCD-RisC). Metabolic traits in obesity and normal BMI in industrialised countries: a multi-country analysis of national populati…

[Department of Error] Department of Error

Parsons H, Metcalfe A, Griffin J, et al. Robotic-arm-assisted versus conventional total knee replacement (RACER-Knee): a pragmatic, multicentre, participant-ma…

[Articles] Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial

Mitapivat, an oral pyruvate kinase activator, with a novel mechanism that ameliorates haemolytic anaemia, has the potential to be an effective and convenient d…

Response to: ‘Comment on: ‘Foundation model-based haemoglobin concentration estimation and anaemia risk assessment from retinal fundus images”

A machine learning-based web application aids Kawasaki disease diagnosis and predicts its outcomes

Parental attitudes toward myopia prevention: insights from an Australian survey

Explainable hybrid ensemble framework for lung cancer classification using deep CNNs and random forest

Exploring clinician interpretability of AI decision support systems for surgical anatomy recognition

Development and internal validation of a nomogram for predicting mechanical ventilation requirement in adult tetanus patients: a dual-center retrospective study

CAR T cells targeting fibroblast activation protein-α for the treatment of pulmonary fibrosis

[Comment] Redefining curative treatment for early-stage mismatch repair-deficient colon cancer

For decades, the standard of care for patients with resected stage II and III colon cancer has centred on surgery with consideration of postoperative adjuvant…

[Articles] Disease-free survival and overall survival after neoadjuvant immunotherapy in mismatch repair-deficient colon cancer in the Netherlands: results of the single-arm, multicentre, phase 2, NICHE-2 trial

In patients with locally advanced dMMR colon cancer, treatment with ipilimumab and nivolumab before surgery resulted in a 3-year disease-free survival and 5-ye…

[Comment] Preserving the uterus: an effective dual therapy to avoid hysterectomy

Heavy menstrual bleeding is a challenging condition that, when refractory to conventional treatment, frequently culminates in hysterectomy. Endometrial ablatio…

[Articles] Endometrial ablation plus levonorgestrel-releasing intrauterine system versus endometrial ablation alone in women with heavy menstrual bleeding in The Netherlands (MIRA2): a multicentre, open-label, randomised, controlled, superiority trial

The combination of endometrial ablation and LNG-IUS significantly reduced the incidence of hysterectomy compared with endometrial ablation alone. The combined…

[Comment] Establishing cardiovascular safety of the small-molecule GLP-1 receptor agonist orforglipron in type 2 diabetes

Cardiovascular outcomes trials with GLP-1 receptor agonists, which to date have largely comprised peptide analogues of the incretin hormone GLP-1, have evolved…

[Comment] Making every vial count: fractional dosing of yellow fever vaccine

Yellow fever is an important public health problem, but vaccine manufacturing cannot be scaled up easily, making it necessary to use existing vaccine stocks to…

[Comment] Shortening treatment to accelerate hepatitis C elimination

Simple oral direct-acting antiviral treatment for hepatitis C virus (HCV) infection has transformed clinical management and paved the way for elimination.1 The…

[Comment] Offline: In praise of astrologers, sorcerers, and magicians

“Prophecies are the grounds on which fights over the future take place”, writes Carissa Véliz in Prophecy: Prediction, Power, and the Fight for the Future, fro…

[World Report] “You have to be willing to take risks”: the 2026 Nobel prizes

Karl Deisseroth, Peter Hegemann, and Georg Nagel have been awarded the 2026 Nobel Prize in Physiology or Medicine. Talha Burki reports.

[World Report] Health in Brazil's election

Ahead of a presidential runoff between Lula and Flávio Bolsonaro, experts outline what is at stake for health. Luke Taylor reports from Rio de Janeiro.

[Perspectives] Shadows and interiority

American television series The Pitt may have redefined the popularity of medical drama, but hospitals have always provided a rich seam for creatives, whether t…

[Perspectives] Beyond the battlefield: war and global health security

During the Syrian war (2011–24), the Assad Government forces and their Russian allies conducted hundreds of strikes on medical facilities in opposition-held ar…

[Perspectives] Temporal rationing: a man with gastric cancer in Colombia

Pepe, a 45-year-old man living in the city of Cali, Colombia, worked as a self-employed hauler of goods with a wheelbarrow. In 2010, he presented to a general…

[Obituary] Roger Detels

Epidemiologist and pioneer in HIV research. Born on Oct 14, 1936, in Brooklyn, New York, NY, USA, he died on July 25, 2026, in Los Angeles, CA, USA, aged 89 ye…

[Correspondence] WHO should adjust its cervical cancer plan

In Gary M Clifford's Comment, he observed that the dominant driver of global inequalities in cervical cancer burden, which are poised to increase dramatically,…

[Correspondence] WHO should adjust its cervical cancer plan – Authors’ reply

We agree with Eric J Suba that current global inequalities in cervical cancer burden are driven largely by unequal access to effective screening programmes. Th…

[Correspondence] Smoking rates: when should harm-reduction evidence be updated?

In their Comment, Ruth Bonita and Robert Beaglehole use New Zealand as an example to argue that smoke-free nicotine products accelerate adult smoking declines,…

[Correspondence] Smoking rates: when should harm-reduction evidence be updated? – Authors’ reply

The striking feature of recent New Zealand smoking trends is the statistically significant acceleration in smoking decline after 2019, not the subsequent plate…

[Correspondence] Underuse of neuromodulation in depression care

As members of the European College of Neuropsychopharmacology Neuromodulation Network, we welcome Gin S Malhi and colleagues’ valuable Seminar on depression.1…

[Correspondence] Underuse of neuromodulation in depression care – Authors’ reply

We thank Roel J T Mocking and colleagues for their comments on our Seminar;1 however, we would like to clarify any confusion over how we have classified neurom…

[Correspondence] Cultural calibration is needed in global mental disorder burden estimates

The Global Burden of Disease (GBD) 2023 Mental Disorder Collaborators provide an indispensable update on the global burden of mental disorders, estimating 1·17…

[Correspondence] Cultural calibration is needed in global mental disorder burden estimates – Authors’ reply

We thank Yasuhiro Kotera for commenting on our Article reporting the global prevalence and burden of mental disorders from the Global Burden of Diseases, Injur…

[Correspondence] Optimising standard of care in non-small-cell lung cancer trials

We read Anwen Xiong and colleagues’ study with great interest.1 Despite the established first-line role of immune checkpoint inhibitors in advanced non-small-c…

[Correspondence] Optimising standard of care in non-small-cell lung cancer trials – Authors’ reply

We thank Emma D A Wagener and Wouter H van Geffen for emphasising the importance of comparator selection. We agree that pembrolizumab plus platinum-based chemo…

[Department of Error] Department of Error

Klein KR, Wysham C, Tuttle KR, et al. Cardiovascular safety of orforglipron versus insulin glargine in adults with type 2 diabetes at increased cardiovascular…

[Department of Error] Department of Error

Murray CJL, Kanem N, Abed S, et al. The Lancet Commission on 21st century global threats to health. Lancet 2026; 408: 1603–61—In this Commission, Prof Lothar H…

[Correspondence] Health care criminalised in Italian immigration detention centres

Immigration detention centres in Italy constitute a substantive health risk for detainees, including risks of infectious and non-communicable diseases and ment…

[Correspondence] Thirlwall, Bier's spots, and the Letby murders

The Thirlwall Inquiry1 was set up to examine events at the Countess of Chester Hospital (Chester, UK) and their implications following convictions for murder a…

[Correspondence] China–Nepal border catastrophic floods: a planetary health alarm

The Hindu Kush Himalayan region, also known as the Third Pole, is warming faster than the global average, with mountain environments experiencing particularly…

[Department of Error] Department of Error

Mocking RJT, Klírová M, Opel N, et al. Underuse of neuromodulation in depression care. Lancet 2026; 408: 1552–53—In this Correspondence, author Maria Semkovska…

Mixture analysis of urinary parabens and their associations with reproductive hormones in iranian women

Mixture analysis of urinary parabens and their associations with reproductive hormones in iranian women

Aspiration-line pressure stability in Venturi and peristaltic pump configurations during phacoemulsification: an in vitro study

Aspiration-line pressure stability in Venturi and peristaltic pump configurations during phacoemulsification: an in vitro study

Improving allergic rhinitis symptoms through nutrition as an adjunct: a systematic review and meta-analysis on the efficacy of dietary supplements

Improving allergic rhinitis symptoms through nutrition as an adjunct: a systematic review and meta-analysis on the efficacy of dietary supplements

Closing surveillance detection gaps for emerging digital drug discourse with ontology-enhanced large language models

Closing surveillance detection gaps for emerging digital drug discourse with ontology-enhanced large language models

Management of skeletal anterior open bite using zygomatic miniplates: a prospective interventional study

Management of skeletal anterior open bite using zygomatic miniplates: a prospective interventional study

Association of cumulative TCBI exposure with incident stroke in cardiovascular kidney metabolic syndrome stages 0 to 3

Association of cumulative TCBI exposure with incident stroke in cardiovascular kidney metabolic syndrome stages 0 to 3

Short-term choroidal thickness modulation with SAT-001 digital software intervention in pediatric myopia: a randomized pilot study

Short-term choroidal thickness modulation with SAT-001 digital software intervention in pediatric myopia: a randomized pilot study

Nutritional assessment and dietary intake patterns in early-stage chronic kidney disease: a hospital-based cross-sectional study

Nutritional assessment and dietary intake patterns in early-stage chronic kidney disease: a hospital-based cross-sectional study

Variable clinical course of retinitis pigmentosa patients with RPE65 gene mutations

Variable clinical course of retinitis pigmentosa patients with RPE65 gene mutations

Adherence to treatment recommendations and quality of life among patients with cardiovascular disease

Adherence to treatment recommendations and quality of life among patients with cardiovascular disease

Physics-informed neural operators for rapid electric field prediction in transcranial magnetic stimulation of healthy and tumor subjects

Physics-informed neural operators for rapid electric field prediction in transcranial magnetic stimulation of healthy and tumor subjects

Pain self-efficacy mediates the relationship between illness perceptions and health-related quality of life in women with endometriosis

Pain self-efficacy mediates the relationship between illness perceptions and health-related quality of life in women with endometriosis

Agreement between initial in-person and follow-up telemedicine assessment in patients presenting with first-time headache

Agreement between initial in-person and follow-up telemedicine assessment in patients presenting with first-time headache

Systemic lupus erythematosus is associated with age-related macular degeneration risk in a nationwide Korean cohort

Systemic lupus erythematosus is associated with age-related macular degeneration risk in a nationwide Korean cohort

Developing national meta-accreditation standards for medical education accreditation bodies in Iran: a mixed-methods standards development and consensus study

Developing national meta-accreditation standards for medical education accreditation bodies in Iran: a mixed-methods standards development and consensus study

Knowledge, attitudes, and practices regarding Helicobacter pylori resistance among physicians: a multicenter cross-sectional study in Shanxi, China

Knowledge, attitudes, and practices regarding Helicobacter pylori resistance among physicians: a multicenter cross-sectional study in Shanxi, China

[Perspectives] Richard Dadd's beguiling art

The Victorian painter Richard Dadd was born in 1817. By the time of his death in 1886 he had been detained in psychiatric hospitals for 42 years. Dadd's life t…

Genetic diversity and low-level infection of Malawi polyomavirus in pediatric patients in Brazil

Genetic diversity and low-level infection of Malawi polyomavirus in pediatric patients in Brazil

Glaucoma practice patterns in Australia and New Zealand: a binational survey of ophthalmologists

Glaucoma practice patterns in Australia and New Zealand: a binational survey of ophthalmologists

Oculomics using artificial intelligence derived retinal biomarkers for cardiovascular health

Oculomics using artificial intelligence derived retinal biomarkers for cardiovascular health

Optogenetic therapy shows early promise for treating retinitis pigmentosa

Optogenetic therapy shows early promise for treating retinitis pigmentosa

Comparison of the effectiveness and dentin loss associated with three contemporary approaches for separated instrument retrieval: an in vitro study

Comparison of the effectiveness and dentin loss associated with three contemporary approaches for separated instrument retrieval: an in vitro study

Feature-dependent agreement between markerless and marker-based motion capture during continuous Taijiquan movement

Feature-dependent agreement between markerless and marker-based motion capture during continuous Taijiquan movement

School connectedness and adverse childhood experiences in relation to suicidal behaviors among nationally representative adolescents

School connectedness and adverse childhood experiences in relation to suicidal behaviors among nationally representative adolescents

Spi1 and Usp7 aggravate diabetic encephalopathy through regulating Ddx3x

Spi1 and Usp7 aggravate diabetic encephalopathy through regulating Ddx3x

Musculoskeletal pain, functional impact, and associations with recorded sex in an adult sample from Mashhad, Iran: a cross-sectional secondary analysis

Musculoskeletal pain, functional impact, and associations with recorded sex in an adult sample from Mashhad, Iran: a cross-sectional secondary analysis

TrajOnco: a multi-agent framework for temporal reasoning over longitudinal EHR for multi-cancer early detection

TrajOnco: a multi-agent framework for temporal reasoning over longitudinal EHR for multi-cancer early detection

Predicting pathogen-positive blood culture episodes at two hours using electronic health record data

Predicting pathogen-positive blood culture episodes at two hours using electronic health record data

Exploring the technical possibilities of metabolomic versus genomic tests for diagnosis of inborn errors of metabolism in NICU

Exploring the technical possibilities of metabolomic versus genomic tests for diagnosis of inborn errors of metabolism in NICU

Lipid–adiposity dissociation in nonagenarians

Lipid–adiposity dissociation in nonagenarians

Triple prophylaxis with fosaprepitant versus dual therapy for postoperative nausea and vomiting in high-risk gynecologic surgery

Triple prophylaxis with fosaprepitant versus dual therapy for postoperative nausea and vomiting in high-risk gynecologic surgery

[Correspondence] Prioritising the future of youth is an urgent political choice

Health professionals and policy makers should fully support the students currently protesting in France.1 Apart from the regrettable outbursts of violence happ…

[Editorial] Rethinking threats to human survival

Much health advocacy is driven by single-issue activism. Communities with a common interest—from AIDS to child health, climate to tobacco control—focus intense…

[Comment] 21st century global threats to health are not what you think

The Lancet Commission on 21st century global threats to health's report by Christopher J L Murray and colleagues uses forecasts based on expected cumulative am…

[Perspectives] John Wong: making an impact on population health at scale

“I’m concerned that the narrative now around ageing populations is one of doom and gloom. But long-lived populations are not the problem. The problem is that w…

New WHO technical package to help countries improve health data for COVID-19 response and beyond

[Comment] Deucrictibant: a novel oral on-demand treatment for hereditary angioedema

Hereditary angioedema due to a deficiency of C1 inhibitor (HAE-C1INH) is clinically characterised by recurrent, generally unpredictable attacks of angioedema.1…

[Comment] Conversational diagnostic AI in primary care: what happens after it speaks?

Patients increasingly use conversational artificial intelligence (AI), including for possible diagnoses, before seeing a clinician. However, clinical evidence…

[Correspondence] Bundibugyo virus: coordinating a cross-border response

On May 15, 2026, the Democratic Republic of the Congo and Uganda declared outbreaks of Ebola disease caused by Bundibugyo virus. On May 17, 2026, the Director-…

[Comment] The role of product safety and liability law in governing digital determinants of health

Digital technologies are transforming societal structures, but this transformation and its public health impacts occur unevenly across the global population.1…

[Perspectives] Barbara Prainsack: practical utopianism for healthier societies

The psychoanalyst and paediatrician Donald Winnicott proposed that a child discovers his or her own self through creative play. This certainly seems to be the…

[Articles] Cardiovascular safety of orforglipron versus insulin glargine in adults with type 2 diabetes at increased cardiovascular risk (ACHIEVE-4): a phase 3, event-driven, randomised, open-label, non-inferiority, active comparator trial

In people with type 2 diabetes at increased cardiovascular risk, the cardiovascular safety of orforglipron was confirmed by demonstrating non-inferiority to in…

[Comment] A novel and effective treatment for fibrodysplasia ossificans progressiva

Fibrodysplasia ossificans progressiva (FOP) is among the most devastating musculoskeletal disorders. FOP is caused by activating variants in ACVR1, most often…

[Articles] Immunogenicity of fractional one-fifth and one-half doses of 17DD yellow fever vaccine compared with full dose in children aged 9–23 months in Uganda: a phase 4, single-blind, randomised clinical trial

Both fractional doses of 17DD yellow fever vaccine were non-inferior to full doses in inducing initial seroconversion. The results support the use of fractiona…

[Comment] The US opioid epidemic at a turning point

After more than a decade of rising mortality, the USA is experiencing an unexpected and encouraging decline in drug overdose deaths. According to provisional e…

[Comment] Indonesia's health reform: from pandemic mandate to the six pillars of transformation

In Indonesia, a large, diverse, middle-income country, the COVID-19 pandemic placed unprecedented pressure on the health system, exposing health inequities and…

WHO Director-General visits Jordan to recognize strong collaboration on health system delivery, emergency relief and advancing mental health

The Director-General of the World Health Organization, Dr Tedros Adhanom Ghebreyesus, today concluded the first day of his two-day State visit to the Hashemite…

WHO statement on notification of withdrawal of the United States

WHO regrets the United States’ notification of withdrawal from WHO – a decision that makes both the United States and the world less safe. The notification of…

Paying tribute to David Nabarro

Tribute to Dr David Nabarro

Timor-Leste certified malaria-free by WHO

The World Health Organization (WHO) has certified Timor-Leste as malaria-free, a remarkable achievement for a country that prioritized the disease and embarked…

African Union and World Health Organization renew strategic partnership to drive impact and strengthen health systems in Africa

The World Health Organization (WHO) and the African Union (AU) Commission renewed their longstanding strategic partnership today with the signing of an updated…

WHO’s strategic engagement with philanthropies: advancing global health and resilient health systems

Philanthropic support plays a vital role in enabling countries to build stronger health systems and advance towards health equity. From vaccine equity and p…

Worldwide rally for maternal and newborn health marks World Health Day 2025

On the occasion of the World Health Day 2025 dedicated to the theme of Healthier beginnings, hopeful futures, over 100 global WHO offices have organized wide-r…

Strengthening public health across Lebanon with EIB Global

Dr Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization (WHO), and Thomas Östros, Vice-President of the European Investment Bank (EIB…

Frank, in-depth discussion as Belgium and WHO map ahead priorities for collaboration

In a three-day strategic dialogue, Belgium and WHO reviewed progress in their longstanding partnership, and agreed to further boost their collaboration on univ…

WHO and Switzerland cement cooperation until 2028

WHO and Switzerland have announced the renewal of their cooperation strategy for the period 2024-2028. In 2013, Switzerland became the first high-income countr…

WHO and the Kingdom of Saudi Arabia sign agreements in support of health priorities

The Riyadh International Humanitarian Forum 2025 was a significant event that underscored the continued partnership between WHO and KSrelief, as well as with o…

WHO comments on United States’ announcement of intent to withdraw

The World Health Organization regrets the announcement that the United States of America intends to withdraw from the organization.

Luxembourg and WHO sign two strategic agreements

A Strategic Partnership Framework (SPF) with the Ministry of Development Cooperation and Humanitarian Affairs and multiyear agreement with the Ministry of Heal…

G20 health ministers rally support for WHO’s Investment Round

Ministers of Health expressed their support for WHO's Investment Round during a G20 meeting chaired by Brazil held today in Rio de Janeiro.

Signing ceremony for contribution agreements between WHO and France

Geneva 17 October 2024 – This afternoon, His Excellency Mr Jérôme Bonnafont, Permanent Representative of France to the United Nations in Gen…

WHO and the Netherlands renew their partnership on climate change and health

The World Health Organization (WHO) and the Kingdom of the Netherlands have renewed their strategic partnership in addressing the growing impacts of climate ch…

The Republic of Korea and WHO discuss joint priorities, challenges and trends around global health

The World Health Organization (WHO) and the Republic of Korea have a long-standing partnership spanning over 75 years. As a result of their fruitful collaborat…

Fourteen African countries, key partners unite to provide critical resources for health in WHO’s first-ever Investment Round

In an unprecedented show of unity in support of the World Health Organization, 14 African countries and many partners pledged over US$ 45 million to the WHO In…

India commits US$ 85 million to WHO Global Traditional Medicine Centre

The WHO-India donor agreement is part of a US$ 250 million investment from India in support of the establishment of the WHO Global Centre of Traditional Medici…

WHO launches unique training course to enable parliamentarians in global health security

The World Health Organization has released "The Role of Parliaments and Parliamentarians in Strengthening Health Security Preparedness", an online training cou…

Qatar Fund for Development (QFFD) supports the implementation of WHO's extended 13th General Programme of Work with flexible funding

Ahead of the Seventy-seventh World Health Assembly , the Qatar Fund for Development (QFFD) and the World Health Organization (WHO) have signed a Core Contribut…

Governments agree to continue their steady progress on proposed pandemic agreement ahead of the World Health Assembly

Governments of the world today agreed to continue working on a proposed pandemic agreement, and to further refine the draft, ahead of the Seventy-seventh World…

Enhancing Global Health and Well-Being: WHO and the Netherlands strengthen their Partnership

WHO and Netherlands Strategic Dialogue in The Hague, Netherlands 10 April 2024. Credit: Michel Mees Photography The WHO and the Netherlands convened in The Hag…

WHO calls for action to uphold right to health amidst inaction, injustice and crises

To mark World Health Day (7 April), the World Health Organization (WHO) is running the “My health, my right” campaign to champion the right to heal…

Digital payments to health workers boost retention, motivation, and impact

An immunization worker gets set up to receive her wages on her mobile wallet in the Democratic Republic of the Congo. Credit: WHO Campaigns in Africa to stop p…

Addressing Global Health Challenges: Irish Taoiseach Varadkar and WHO Director-General in Dublin Talks

France signs agreements to support WHO's work

©WHO/Chris B. Geneva – His Excellency Jérôme Bonnafont, Permanent Representative of France to the United Nations in Geneva, and Dr Tedr…

Canada and WHO pursue closer engagement on gender, equity, universal health coverage and more

In a full day of meetings on 20 November, WHO leaders and a Canadian government delegation reflected o…

Germany reaffirms its commitment to WHO and key health priorities

A leading flexible contributor, the Netherlands renews its multiannual allocation to WHO

The Netherlands reaffirmed its position as a key supporter and strategic partner of WHO and a leading donor of flexible and predictable resources to WHO. In pi…

France's new Global Health Strategy

France has released its Global Health Strategy for 2023-2027, in Lyon today, in the presence of three French Ministers, the Minister for Europe and Foreign Aff…

UNHCR, WHO warn of deteriorating health conditions as 1200 children die of suspected measles, malnutrition in Sudan

UNHCR, the UN Refugee Agency, and the World Health Organization (WHO) are again sounding the alarm on the worsening health situation caused by the Sudan crisis.

First WHO report details devastating impact of hypertension and ways to stop it

The World Health Organization (WHO) released its first-ever report on the devastating global impact of high blood pressure, along with recommendations on the w…

OCHA and WHO annual consultation

Geneva, 21 June - Representatives of WHO and the United Nations Office for the Coordination of Humanitarian Affairs (OCHA) focused their annual financial and m…

WHO and the UK hone their collaboration against pandemics, other health threats

Pandemic preparedness, support for Ukraine, and the fight against superbugs topped the agenda Tuesday as WHO and UK health leaders met in London to discuss the…

WHO sends health supplies to reach 400 000 people impacted by the earthquakes in Türkiye and the Syrian Arab Republic

In response to the devastating earthquakes impacting Türkiye and the Syrian Arab Republic, the World Health Organization delivered 72 metric tons of traum…

Ukraine next country to receive technology from the WHO mRNA technology transfer hub

Ukraine has joined the growing list of countries that will receive support from the global WHO mRNA technology transfer hub in South Africa. The manufacturer,…

COVID-19 disrupting mental health services in most countries, WHO survey

The COVID-19 pandemic has disrupted or halted critical mental health services in 93% of countries worldwide while the demand for mental health is increasing, a…

Global partnership to make available 120 million affordable, quality COVID-19 rapid tests for low- and middle-income countries

Managing the COVID-19 infodemic: Promoting healthy behaviours and mitigating the harm from misinformation and disinformation

The Coronavirus disease (COVID-19) is the first pandemic in history in which technology and social media are being used on a massive scale to keep people safe,…

WHO’s three messages for UNGA75

As the world comes together at an unprecedented virtual session of the 75th UN General Assembly (UNGA), WHO has three messages to share.

COVID-19 could reverse decades of progress toward eliminating preventable child deaths, agencies warn

In WHO global pulse survey, 90% of countries report disruptions to essential health services since COVID-19 pandemic

WHO to roll out learning and monitoring tools to improve service provision during pandemic The World Health Organization (WHO) today published a first indicati…

Global polio eradication initiative applauds WHO African region for wild polio-free certification

Today, the Africa Regional Certification Commission certified the WHO African Region as wild polio-free after four years without a case. With this historic mil…

World Humanitarian Day 2020: A tribute to aid workers on the front lines

Amid a global pandemic, unprecedented needs and growing insecurity, aid workers and health-care responders are staying and delivering to the world’s most…

Plane carrying WHO trauma and surgical supplies arrives in Beirut, Lebanon

A plane carrying 20 tonnes of WHO health supplies has landed in Beirut, Lebanon, to support the treatment of patients injured by the massive blast that occurre…

COVID-19 Emergency Committee highlights need for response efforts over long term

The Emergency Committee on COVID-19, convened by the WHO Director-General under the International Health Regulations (2005) (IHR), held its fourth meeting on 3…

WHO statement on heated tobacco products and the US FDA decision regarding IQOS

WHO takes this opportunity to remind Member States that are Parties to the WHO Framework Convention of Tobacco Control (FCTC) of their obl i gations under the…

World Hepatitis Day: fast-tracking the elimination of hepatitis B among mothers and children

On World Hepatitis Day 2020, WHO is calling for united and stepped-up action to prevent mother-to-child transmission of hepatitis B (HBV), a preventable viral…

New COVID-19 Law Lab to provide vital legal information and support for the global COVID-19 response

Launching today, the COVID-19 Law Lab initiative gathers and shares legal documents from over 190 countries across the world to help states establish and imple…

WHO Director-General pays tribute to Spain’s sacrifices and leadership to confront COVID-19

World Health Organization Director-General Dr Tedros Adhanom Ghebreyesus today joined the leadership of Spain, paying homage to those who have lost their lives…

WHO and UNICEF warn of a decline in vaccinations during COVID-19

WHO and UNICEF call for immediate efforts to vaccinate all children as new data shows that, before the COVID-19 pandemic, vaccine coverage stalled at 85 per ce…

As more go hungry and malnutrition persists, achieving Zero Hunger by 2030 in doubt, UN report warns

Rome – More people are going hungry, an annual study by the United Nations has found. Tens of millions have joined the ranks of the chronically undernour…

Independent evaluation of global COVID-19 response announced

PWHO Director-General today announced the initiation of the Independent Panel for Pandemic Preparedness and Response (IPPPR) to evaluate the world’s resp…

UN Public Service Day

Honouring the public servants who have been working on the frontlines of the COVID-19 pandemic. Whether working in healthcare or delivering essential services…

WHO experts to travel to China

WHO experts will travel to China to work together with their Chinese counterparts to prepare scientific plans for identifying the zoonotic source of the SARS-C…

WHO: access to HIV medicines severely impacted by COVID-19 as AIDS response stalls

Seventy-three countries have warned that they are at risk of stock-outs of antiretroviral (ARV) medicines as a result of the COVID-19 pandemic, according to a…

WHO discontinues hydroxychloroquine and lopinavir/ritonavir treatment arms for COVID-19

WHO today accepted the recommendation from the Solidarity Trial’s International Steering Committee to discontinue the trial’s hydroxychloroquine an…

Listings of WHO’s response to COVID-19

WHO provides this timeline of the organization’s COVID-19 response activities for general information. WHO will update the timeline on a regular basis and in l…

ACT-Accelerator update

IOC joins forces with WHO and the United Nations to fight COVID-19

The International Olympic Committee and WHO together with the United Nations launch a partnership to encourage individuals and communities around the world to…

The World Health Organization reminds public to remain vigilant through Mr Bean’s Essential COVID-19 Checklist

Public Service Announcement reminds people about the importance of washing hands, physical distancing and showing kindness The World Health Organization (WHO),…

Countries failing to prevent violence against children, agencies warn

WHO welcomes preliminary results about dexamethasone use in treating critically ill COVID-19 patients

The World Health Organization (WHO) welcomes the initial clinical trial results from the United Kingdom (UK) that show dexamethasone, a corticosteroid, can be…